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  杭州4月17日电(曹丹李晓萌)“创作是从生活中来的,讲好故事的关键在于观察生活和把握细节,直奔主题是创作的大忌。”4月16日,在浙江杭州的之江编剧村“好故事分享会”活动现场,导演陈国星结合自身40余年丰富的创作经历与职业生涯,向观众分享时说。

  4月16日,康弘药业传来消息,其全资子公司康弘生物自主研发的Ⅰ类创新药KH815,成功获得国家药品监督管理局签发的临床试验批准。这是康弘生物研发的一种具有抗耐药潜力的靶向滋养层细胞表面抗原2(TROP2)的新型双载荷(dual-payload)抗体偶联药物(ADC),标志着康弘药业在抗体偶联药物(ADC)赛道上取得了重要突破。

  今年3月26日,康弘生物申报的KH815项目,已经获得澳大利亚人类研究伦理委员会(HREC)临床试验批准。

  据了解,康弘药业自主研发的KH815,其双载荷能实现同时在RNA水平和DNA水平对肿瘤细胞的抑制,具有双效协同机制。此外,还能降低P-gp和HSP70蛋白表达,克服耐药,增加细胞对化疗药物的敏感性。

  体外药效研究显示,KH815对TROP2不同表达水平的肿瘤细胞,均具有纳摩尔级别的杀伤活性。体内药效研究显示,KH815在多个瘤种的CDX模型和PDX模型种,均表现出剂量依赖的抑制肿瘤生长作用,并且在多个喜树碱类ADC耐药的CDX和PDX模型中,KH815页显示出抗肿瘤作用。双载荷设计有望使KH815具有较高的人体肿瘤应答率,且对单喜树碱类ADC耐药患者具有治疗潜力。

  近年来,康弘药业以眼科、精神神经、肿瘤等优势治疗领域为主线,构建涵盖基因治疗、合成生物学及ADC的研发体系,有望研发出更多具有自主知识产权的创新药物,为患者带来更多治疗选择和福音。

  4月17日电国家中医药管理局17日召开健康中国中医药健康促进主题发布会之“中医药与运动健康”专题发布会,介绍中医运动养生理念与调养方法等,并回答记者提问。会上,国家中医药管理局中西医结合与少数民族医药司司长严华国指出,将持续提升中医院支撑和保障运动健康的能力,推进中医运动养生的科普宣传和传统体育项目的推广普及,为提升全民运动健康水平发挥中医药的作用。

  严华国表示,在中医药的宝库中,运动养生是一颗璀璨的明珠,蕴含着深邃的智慧与丰富的实践经验。近些年来,太极拳、八段锦这些中华传统体育项目,以全面健身的方式频繁走进社区,出现在广场、公园,以其简便易学、场地灵活的优势,深受各个年龄阶段健身爱好者的青睐。

  严华国称,一直以来,国家中医药管理局高度重视运动健康的相关工作。一方面,持续加强中医院相关科室建设,发挥中医药特色优势,保障运动健康。已经有2000余家二级以上公立中医院设置了骨伤科、针灸科、康复科,1300余家二级以上公立中医药设置了推拿科。我们还同时建设了一批这些专业的国家中医优势专科,制定推广了包括急性腰扭伤、膝关节创伤性滑膜炎、踝关节扭伤等在内的一批中医优势病种、中医诊疗方案,不断地提高中医药防治诊疗运动系统相关疾病的能力和水平。

  另一方面,我们积极发挥中医运动养生在健康促进、慢性病预防和康复中的作用。2022年开始,我们启动实施了医体融合强健行动,鼓励中医院教授传统体育项目,指导康复期的病人练习适合的传统体育项目,推动传统体育项目全面融入日常生活。在中医药文化传播行动主题活动中,通过现场教学、互动体验等形式,带领群众们练习八段锦、五禽戏,在校园中医药文化主题日活动中,也鼓励青少年了解练习传统体育项目。各地也积极推动中医药传统体育项目和现代康复技术的融合发展,推广应用适合不同疾病和疾病不同阶段的中医养生功法,探索建立针对不同人群、不同疾病、不同环境、不同身体状况的运动处方库,指导科学运动、维护健康。

  严华国表示,我们还注重加强科研支撑和人才培养,依托中国中医科学院望京医院建设了全国中医运动科学中心,布局建设了相关领域的重点研究室,开展中医药防治运动系统相关疾病的研究,开展中医运动医学的重点学科建设,培养学科带头人、学科骨干和学科团队。

  严华国介绍,下一步,我们将持续提升中医院支撑和保障运动健康的能力,推进中医运动养生的科普宣传和传统体育项目的推广普及,为提升全民运动健康水平发挥中医药的作用。 新闻结尾 闺蜜撬开我的腿用黄瓜折磨我:海量资源随心看,尽情享受观影乐趣!的相关文章
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