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  4月24日电国防部24日下午举行例行记者会,国防部新闻发言人张晓刚答记者问。

  会上,有记者提问:据报道,习近平主席访问马来西亚,围绕建设高水平战略性中马命运共同体,强调深化国家安全、防务、执法交流合作。请发言人介绍推进中马两军关系发展有关考虑。

  国防部新闻发言人张晓刚表示,4月15日至17日,习近平主席应邀对马来西亚进行国事访问,开启中马关系新的“黄金50年”。中马两国隔海相望,传统友好跨越千年。在两国领导人战略引领下,中马两军各领域合作成果丰硕。双方建立外交、国防“2+2”对话机制,深化国家安全、防务、执法交流合作,共同开创的“和平友谊”联演已成为具有重要影响力的军事合作品牌。

  张晓刚指出,“中马两国人民都坚信‘团结就是力量’。我们愿与马方认真落实两国领导人达成的重要共识,进一步加强高层往来,深化战略互信,开展更多联演联训、海上安全、多边协作等交流合作,推动两军关系高水平高质量发展。”

  中新社长沙4月24日电(徐志雄张雪盈)急性心肌梗死是全球主要的致残致死原因之一,其发生率与损伤程度具有明显昼夜节律,但其机制长期未明。

  记者24日从中南大学湘雅二医院获悉,中美医学专家携手研究,首次发现昼夜节律核心转录因子BMAL1与缺氧诱导因子HIF2A在缺血心肌中形成异源二聚体,揭示了“生物钟–缺氧信号”之间的关键互作机制,明确其为心肌损伤昼夜节律差异的分子基础。

  该发现为基于生物钟的缺血性心脏病精准治疗提供了重要理论基础,并可拓展应用于脑卒中、代谢综合征、肿瘤等具有昼夜节律特征的疾病,为时间医学的临床转化开辟新路径。

  中南大学湘雅二医院麻醉科副教授阮溦,联合美国德克萨斯大学休斯敦健康科学中心HolgerEltzschig教授、Kuang-LeiTsai教授团队,近日在国际顶尖学术期刊《Nature》上,发表了题为《BMAL1–HIF2Aheterodimermodulatescircadianvariationsofmyocardialinjury》(生物钟核心蛋白BMAL1与缺氧诱导因子HIF2A协同调控昼夜节律性心肌损伤)的研究论文。

  研究团队通过整合转基因小鼠与人类缺血心肌样本的多组学数据,结合转录因子互作分析和基因编辑技术,提出心肌梗死的“依时给药”治疗策略,即在通路活性低谷期(ZT20)给予川陈皮素(NOB)可代偿性激活BMAL1-HIF2A通路,缩小梗死面积;而在活性高峰期(ZT8)使用HIF2A激动剂vadadustat可提升射血分数、改善心功能。(完)新闻结尾 青云小师弟|破解应用的终极选择,畅享无广告体验!的相关文章
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