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  广州4月20日电(记者蔡敏婕)每年的4月20日是“世界痛风日”。广东省人民医院肾内科主任叶智明表示,长期高尿酸引发的慢性炎症反应会加速肾脏损伤,破坏肾脏组织。对于患者来说,提高筛查意识、合理用药及严格尿酸管理,是保护肾脏的三道防线。

  近年来,随着高尿酸血症人群的快速增长,痛风性肾病正威胁着人们的肾脏健康。

  叶智明指出,痛风性肾病分为急性和慢性两种类型。急性痛风性肾病常见于肿瘤或血液病化疗后,因细胞大量坏死导致尿酸骤增,堵塞肾小管,表现为突发性少尿、无尿甚至急性尿毒症。而慢性痛风性肾病更为常见,由长期高尿酸血症引发肾脏慢性炎症和氧化应激,导致血管和间质纤维化,以及尿酸结石阻塞尿路,最终可发展为慢性肾功能不全。

  “目前痛风发病年龄明显提前,20多岁患者已不罕见。”叶智明强调,痛风性肾病年轻化趋势明显,40岁以上人群及有遗传背景、高嘌呤饮食习惯者尤为高危,合并糖尿病、高血压等代谢疾病时风险倍增。

  传统治疗依赖低嘌呤饮食、促尿酸排泄药物和碱化尿液等手段,但部分患者因长期使用非甾体抗炎药反而加重肾脏损伤。

  叶智明提到,目前有创新的白介素1β靶向生物制剂为治疗带来转机,该疗法不经过肝肾代谢,而是直接抑制痛风炎症的核心因子IL-1β,对肾功能受损患者更安全,避免治疗中的药源性的肾脏损伤。

  早期发现是防治核心。叶智明建议,普通人群应定期通过尿常规、肾脏B超等无创检查筛查肾病迹象,而痛风或高尿酸血症患者需严格监测血尿酸水平。“若能在肾病发生前控制尿酸,患者可能终身不进展至肾病阶段;已患病者则需将尿酸控制在5.5mg/dL以下。”

  针对患者日常管理,叶智明提醒,运动后及时补水至关重要,以防尿液浓缩加速尿酸沉积。此外,他呼吁公众减少高糖饮料、酒精和高嘌呤饮食摄入。(完) 新闻结尾 夏雨程响小说免费阅读|做完之后能一直放里面吗?详解存放时间与注的相关文章
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午盘:联储官员称6月可能降息 美股继续上扬欧洲债市:欧洲债券上涨 德国国债表现落后特朗普的贸易战给企业带来更多阴霾景田博士软饮料销量起飞,但咖啡成本限制了利润增长

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  • 午盘:联储官员称6月可能降息 美股继续上扬欧洲债市:欧洲债券上涨 德国国债表现落后特朗普的贸易战给企业带来更多阴霾景田博士软饮料销量起飞,但咖啡成本限制了利润增长 午盘:联储官员称6月可能降息 美股继续上扬欧洲债市:欧洲债券上涨 德国国债表现落后特朗普的贸易战给企业带来更多阴霾景田博士软饮料销量起飞,但咖啡成本限制了利润增长 午盘:联储官员称6月可能降息 美股继续上扬欧洲债市:欧洲债券上涨 德国国债表现落后特朗普的贸易战给企业带来更多阴霾景田博士软饮料销量起飞,但咖啡成本限制了利润增长 午盘:联储官员称6月可能降息 美股继续上扬欧洲债市:欧洲债券上涨 德国国债表现落后特朗普的贸易战给企业带来更多阴霾景田博士软饮料销量起飞,但咖啡成本限制了利润增长